A recent discovery about an Alzheimer’s drug may lead to the end of cavity fillings in teeth as we know them.
Scientists discovered the drug, Tideglusib, promoted natural tooth regrowth during its clinical trials on mice, which led to total repair of cavities. They learned the drug stimulates stem cells in teeth, which creates new dentine — the substance beneath tooth enamel that’s eroded by decay when a cavity forms.
When the researchers realized the drug was promoting tooth regeneration, they soaked collagen fillers in Tideglusib, inserted them into cavities and saw the tooth craters disappear within six weeks. After the collagen structures melted away, what remained was a healthy, cavity-free tooth. But the experiment has only been conducted on mice so far.
“Using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics,” lead author of the study Paul Sharpe told The Telegraph. “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine.”